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Heparin is contraindicated in patients known to have hypersensitivity to heparin. It is also contraindicated when suitable blood coagulation tests - e.g the whole-blood clotting time, partial thromboplastin time, cannot be performed at the required intervals. There is usually no need to monitor the effect of low dose heparin in patients with normal coagulation parameters. The drug is contraindicated during any uncontrolled active bleeding state (see Warnings).
Heparin without preservative should be used in premature infants.
